I haven't tried Studio64 for about a year,but back then I found it to be slightly less polished then Ubuntu Studio, as is to be expected. Basically, do you prefer debian or Ubuntu? Aside from that they both pretty much had all the same packages. I have not had a good experience with any 64 bit version of Linux(Ok I only tried those two). I saw reduced stability and performance running audio recording software with RT kernels on a Turion 64 with 2GB DDR2700. Granted this was a kinda old laptop I was using, and things may have gotten better with the stability since then. However from what I understand, you need to have a lot of memory (4G or more) and be running memory intensive apps before you see any benefit from running a 64 bit OS due to the increased overhead in addressing a memory bus that is twice a wide. I could be wrong about this, and would certainly appreciate any input from anybody with more in depth and/or recent experience on the 64b front. bnr